Arrhythmias & electrophysiologyRandomised controlled trial
Systematic, randomised atrial fibrillation screening using detailed phenotyping with a risk-prediction model combined with patch electrocardiogram in a Swedish population aged 65 years or older: The CONSIDERING-AF trial
- Randomised controlled trial
Authors' conclusion
Among high-risk individuals ≥ 65 years, the combination of a machine learning-based RPM and long-term ECG recording was superior to standard care in identifying new AF cases.
Study context
- Population
- Individuals ≥ 65 years, Swedenparticipation 43% (632/1480) in invitation arms
- Participants
- 2,960 individuals
- Comparison
- Atrial fibrillation (AF) screening with risk prediction model (RPM) + 14-day patch electrocardiogram (ECG) vs standard care
- General + controln = 740reference
- General + invitationn = 740
- RPM + controln = 740
- RPM + invitationn = 740
- Primary endpoint
- AF incidence (RPM + invitation vs general + control)
- Follow-up
- 6 months
Primary result
As reported in the abstract
Relative risk
5.6
95% CI 2.2–14.4
P < 0.001
Events by treatment group
RPM + invitation vs General + control
RR 5.6 (95% CI 2.2–14.4); P < 0.001
Further findings
| Outcome | General + control | General + invitation | RPM + control | RPM + invitation | P value |
|---|---|---|---|---|---|
| AF incidence, other arm comparisons — RPM + invitation vs General + invitation | Not reported in the abstract | 1.1% | 2.2% | Not reported in the abstract | P < 0.001 |
| AF incidence, other arm comparisons — RPM + invitation vs RPM + control | P = 0.07 | ||||
| AF incidence, other arm comparisons — General + invitation vs General + control · no difference | P = 0.40 |
Original publication
Systematic, randomised atrial fibrillation screening using detailed phenotyping with a risk-prediction model combined with patch electrocardiogram in a Swedish population aged 65 years or older: The CONSIDERING-AF trial. Europace. Published 22 August 2025. doi:10.1093/europace/euaf190
Summarised from the published abstract; every number is checked against it