Heart failure & cardiomyopathiesMeta-analysis
Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency
- Systematic review and meta-analysis of randomised trials
- Bayesian
- individual participant data from five trials
Authors' conclusion
These findings suggest that treating iron deficiency in patients with HF significantly reduces cardiovascular events
Study context
- Population
- Patients with heart failure (HF) and iron deficiency
- Participants
- 7,175 patients · 6 trials
- Comparison
- IV iron vs placebo
- Outcome
- Composite of:
- Recurrent HF hospitalizations
- CV mortality
- Follow-up
- 12 months
Pooled result
Recurrent HF hospitalizations and CV mortality
Relative risk
0.72
95% CI 0.55–0.89
IV iron vs Placebo
RR 0.72 (95% CI 0.55–0.89)
As reported in the abstract
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Recurrent HF hospitalizations and CV mortality · complete length of follow-up | RR 0.81 (95% CI 0.63–0.97) | |
| Recurrent HF hospitalizations · 12 months and complete length of follow-up — IV iron vs Placebo | RR 0.69 (95% CI 0.48–0.88) | |
| Recurrent HF hospitalizations · 12 months and complete length of follow-up — IV iron vs Placebo · complete follow-up | RR 0.78 (95% CI 0.55–0.98) | |
| CV mortality · 12 months and complete length of follow-up — IV iron vs Placebo | HR 0.80 (95% CI 0.61–1.03) | |
| CV mortality · 12 months and complete length of follow-up — IV iron vs Placebo · complete follow-up | HR 0.87 (95% CI 0.73–1.04) | |
| All-cause mortality · 12 months and complete length of follow-up — IV iron vs Placebo | HR 0.82 (95% CI 0.65–1.03) | |
| All-cause mortality · 12 months and complete length of follow-up — IV iron vs Placebo · complete follow-up | HR 0.92 (95% CI 0.80–1.07) | |
| 0.512Ratio (log scale) |
Original publication
Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency. Nat Med. Published 30 March 2025. doi:10.1038/s41591-025-03671-1
Summarised from the published abstract; every number is checked against it