Acute cardiac care & resuscitationSecondary analysis
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock
- Secondary analysis of the Danish-German (DanGer) Shock randomised trial
- post hoc analysis
- open-label
- multicentre
Authors' conclusion
Randomization SBP was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit.
Study context
- Population
- Adults with STEMI complicated by cardiogenic shock, 14 tertiary cardiac centres in Denmark, Germany and the UK, 2013–2023of 355 in trial
- Participants
- 351 adults
- Comparison
- Microaxial flow pump vs Standard care
- Primary endpoint
- All-cause mortality according to randomization SBP
- Follow-up
- 180 days
Primary result
As reported in the abstract
All-cause mortality by randomization SBP (subgroups)
Microaxial flow pump vs Standard careOdds ratio (95% CI)P value
SBP lower than 82 mm Hg
0.34(0.18–0.63)
P < 0.001higher SBP
0.96(0.53–1.70)
P = 0.90Further findings
Kaplan-Meier survival and spline regression analyses
- Supported the findings; P for interaction
- P = 0.02
- P for nonlinearity
- P = 0.01
Original publication
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock. JAMA Cardiol. Published 1 November 2025. doi:10.1001/jamacardio.2025.3337
Summarised from the published abstract; every number is checked against it