Heart failure & cardiomyopathies
Systolic Blood Pressure and Pulse Pressure in Heart Failure: Pooled Participant-Level Analysis of 4 Trials
Authors' conclusion
Our analysis of a large pooled dataset from 4 clinical trials, including >16,900 patients with HFmrEF/HFpEF, indicates a J-shaped relationship between both SBP and PP and cardiovascular risk. The lowest risk was observed at SBP levels between 120 and 130 mm Hg and PP values between 50 and 60 mm Hg
Study context
- Population
- Patients with HFmrEF or HFpEF (LVEF ≥40% in DELIVER, ≥45% in I-PRESERVE, TOPCAT-Americas, PARAGON-HF)
- Participants
- 16,950 patients · 4 trials
- Comparison
- Baseline systolic blood pressure (SBP) categories and pulse pressure (PP) quartiles
- Outcome
- First HF hospitalization or CV death
Methodological detailsrestricted cubic splines
- Restricted cubic splines
Pooled result
As reported in the abstract
Hazard ratio (95% CI)
SBP ≥140 vs SBP 120-129
1.22(1.10–1.34)
Highest PP quartile vs PP quartile 46-54
1.22(1.11–1.34)
Original publication
Systolic Blood Pressure and Pulse Pressure in Heart Failure: Pooled Participant-Level Analysis of 4 Trials. J Am Coll Cardiol. Published 15 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it