Cohort study
Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death
- Prospective cohort study
- UK Biobank
Authors' conclusion
An increase in SBPV over time was associated with an elevated risk of CVD, CKD, and overall mortality.
Study context
- Population
- UK Biobank participants in primary care with ≥3 SBP values at 5–10 and 0–5 years before enrolment
- Participants
- 36,251 participants
- Exposure
- Change in visit-to-visit systolic blood pressure variability (SBPV) between two periods before enrolment
- Outcome
- CVD, CHD, stroke, AF, HF, CKD, dementia and overall mortality
- Follow-up
- Median 13.9 years
Main finding
As reported in the abstract
CVD, CHD, stroke, CKD, overall mortality
Increased SBPV from Period 1 to Period 2 significantly associated with increased risk of cardiovascular disease (CVD), coronary heart disease (CHD), stroke, chronic kidney disease (CKD) and overall mortality (all P for trend < .005)
23%-33%
Observational data: associations, not effects.
Further findings
Non-linearity (restricted cubic spline)
- No non-linear associations
- >.05
SBPV change patterns: consistently high vs consistently low SBPV
- Increased risk of CVD, CHD, stroke, and flutter (AF), heart failure (HF), CKD and overall mortality
- 28%-46%
Subgroup and sensitivity analyses
- Associations remained largely unchanged
Original publication
Systolic blood pressure variability: risk of cardiovascular events, chronic kidney disease, dementia, and death. Eur Heart J. Published 18 April 2025. doi:10.1093/eurheartj/ehaf256
Summarised from the published abstract; every number is checked against it