Arrhythmias & electrophysiologyDiagnostic or prognostic study
Tau20-RETROmapping System Identifies Driver-Like Activation Patterns in Real Time During Persistent Atrial Fibrillation
- Validation study of an investigational mapping system
Authors' conclusion
The Tau20-RETROmapping system enables real-time activation mapping of AF, with the most convincing driver-like areas being identified around the LAA.
Study context
- Population
- Patients undergoing pulmonary vein isolation for atrial fibrillation (AF)patients undergoing pulmonary vein isolation for AF · sinus rhythm or atrial tachycardia (AT) Six · mapped in AF Eighteen
- Participants
- 24 patients
- Comparison
- Tau20-RETROmapping system against manual validation of randomly sampled local electrograms
Performance
As reported in the abstract
Diagnostic accuracy in sinus rhythm or AT
sensitivity
100.0% (95% CI, 80.5%-100.0%)
specificity
100.0% (85.2%-100.0%)
Further findings
Identifying organized AF wavefronts
- sensitivity
- 94.4% (86.2%-98.4%)
- specificity
- 97.1% (89.9%-99.6%)
- accurately identified the earliest activation, of waves
- 89.6% (79.7%-95.7%)
Propagation patterns relative to the left atrial appendage (LAA) during AF
- Stable propagation originating from the LAA
- 3/18 patients
- Competing propagation toward and away from the LAA
- 8/18
- Conduction away from the LAA along the anterior wall
- 8/18 patients
- Conduction away from the LAA along the lateral wall
- 8/18 patients
- Conduction away from the LAA along the posterior wall
- 7/18 patients
- No propagation near the LAA
- 6/18 patients
Original publication
Tau20-RETROmapping System Identifies Driver-Like Activation Patterns in Real Time During Persistent Atrial Fibrillation. Circ Arrhythm Electrophysiol. Published 2 July 2026. doi:10.1161/circep.126.015039
Summarised from the published abstract; every number is checked against it