Valvular & structural heart disease
Temporal Changes in Procedural Success and Clinical Outcomes of MTEER by Mechanism of MR: Analysis of the STS/TVT Registry
Authors' conclusion
The application of mitral transcatheter edge-to-edge repair for nondegenerative etiologies increased considerably. While the odds of technical success were higher for all etiologies except acute ischemic MR, a similar 1-year mortality risk was observed in nondegenerative etiologies compared with DMR in real-world settings. These data support the use of mitral transcatheter edge-to-edge repair in degenerative and nondegenerative etiologies.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair in the STS/TVT registry, 2013 to 2023, excluding patients in shock, grouped by mechanism of mitral regurgitation (MR)patients included
- Participants
- 68,028 patients
- Exposure
- Mechanism of MR compared with degenerative MR, across time periods
Main finding
As reported in the abstract
Increasing from
19%
To
43%
Observational data: associations, not effects.
Further findings
| Outcome | Risk | P value |
|---|---|---|
| 1-year heart failure readmission — ventricular functional MR vs DMR · risk not higher than for DMR · multivariable analyses | P = 0.10642 | |
| 1-year heart failure readmission — chronic ischemic MR and atrial MR vs DMR · even if they had a successful procedure · multivariable analyses | 19% higher | P = 0.00493 |
Technical success
- Excluding acute ischemic MR, the odds of technical success were significantly higher for all mechanisms compared with degenerative MR (DMR)
Procedures using only 1 implanted device
- 2022-2023
- 64.7%
- 2013-2017
- 54.6%
- Without negatively impacting technical success
1-year mortality
- The risk of 1-year mortality was not higher in nondegenerative etiologies compared with DMR
Interaction between MR mechanism and time
- There was no statistically significant interaction between MR mechanism and time in outcomes analyses
Original publication
Summarised from the published abstract; every number is checked against it