HypertensionMeta-analysis
Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review
- Systematic review
- synthesis without meta-analysis
- vote-counting based on direction of effect
Ovid/MEDLINE, EMBASE and ClinicalTrials.gov searched up to February 2023; 7644 articles screened
Authors' conclusion
The majority of target organ damage reported during a hypertensive pregnancy remains evident throughout the early and late post-partum period despite variation in blood pressure.
Study context
- Population
- Women with hypertensive pregnancy, from pregnancy to postpartum76 studies (pregnancies)
- Participants
- 1,742,698 women
- Outcome
- BP trajectories and target organ damage (cardiac, vascular, cerebral, renal)
- Follow-up
- Pregnancy to postpartum
Pooled result
As reported in the abstract
- LV hypertrophy, white matter lesions, proteinuria and retinal microvasculature changes first evident during hypertensive pregnancy
- Cardiac, cerebral and retinal changes also reported early and late postpartum despite reduction in BP early postpartum
- Cognitive dysfunction first reported late postpartum
- only higher quality studies used for final analysis
Original publication
Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review. Eur J Prev Cardiol. Published 22 August 2023. doi:10.1093/eurjpc/zwad275
Summarised from the published abstract; every number is checked against it