Valvular & structural heart diseaseCohort study
Temporal Trends in 1-Year Cause-Specific Mortality After Transcatheter Aortic Valve Replacement (TAVR)
- Retrospective registry cohort study
- STS/ACC TVT Registry
- competing-risk (Fine and Gray) analysis
Authors' conclusion
Noncardiac causes account for two-thirds of deaths within 1 year after TAVR.
Study context
- Population
- Patients who underwent isolated TAVR, Jan 2012–Oct 2022, who died within 1 year with available CoDdeaths within 1 year
- Participants
- 36,877 patients
- Outcome
- Cause-specific (cardiac and noncardiac) mortality
- Follow-up
- 1 year
Main finding
As reported in the abstract
Cause of 1-year death after TAVR
- Cardiac death
- 11,560 (31.3%)
- Noncardiac death
- 25,317 (68.7%)
- Cardiac death, adjusted HR per year 2012–2017
- 0.95 (95% CI 0.92-0.97)
- Noncardiac death, adjusted HR per year 2012–2017
- 0.92 (95% CI 0.90-0.93)
- Cardiac death, adjusted HR per year 2018–2022
- 1.07 (95% CI 1.05-1.09)
- Noncardiac death, adjusted HR per year 2018–2022
- 1.22 (95% CI 1.20-1.24)
Observational data: associations, not effects.
Further findings
Independent predictors of both cardiac and noncardiac death
- Age >80 years, comorbidities, poor functional status, nonelective procedure, nonfemoral access, in-hospital complications
Original publication
Temporal Trends in 1-Year Cause-Specific Mortality After TAVR. JACC Cardiovasc Interv. Published 19 March 2025. doi:10.1016/j.jcin.2024.12.016
Summarised from the published abstract; every number is checked against it