Coronary disease & ACSCohort study

Temporal Trends in Noncardiovascular Morbidity and Mortality Following Acute Myocardial Infarction

J Am Coll CardiolPublished

  • Registry-based nationwide cohort study

Authors' conclusion

Although cardiovascular mortality following MI improved substantially during 2000 to 2017, the risk of noncardiovascular morbidity increased. Moreover, noncardiovascular causes constitute an increasing proportion of post-MI mortality.

Study context

Population
All Danish patients with myocardial infarction (MI), 2000 to 2017
Participants
136,293 consecutive patients
Exposure
2015 to 2017 vs 2000 to 2002
Outcome
CV and noncardiovascular mortality, incident cancer, incident renal disease, severe infectious disease
Follow-up
1 year

Main finding

As reported in the abstract

1-year risk

2000 to 2002

18.4%

CV mortality · Noncardiovascular mortality 5.8% · Proportion of total mortality noncardiovascular 24.1% · Incident cancer 1.9% · Incident renal disease 1.0% · Infectious disease 5.5%

2015 to 2017

7.6%

CV mortality · Noncardiovascular mortality 5.0% · Proportion of total mortality noncardiovascular 39.5% · Incident cancer 2.4% · Incident renal disease 1.6% · Infectious disease 9.1%

2015 to 2017 vs 2000 to 2002Standardized relative risk (95% CI)
cancer; standardized for patient characteristics
0.99(0.91–1.07)
renal disease; standardized for patient characteristics
1.28(1.15–1.41)
infectious disease; standardized for patient characteristics
1.28(1.23–1.34)

Observational data: associations, not effects.

Original publication

Temporal Trends in Noncardiovascular Morbidity and Mortality Following Acute Myocardial Infarction. J Am Coll Cardiol. Published 5 September 2023. doi:10.1016/j.jacc.2023.06.024

Summarised from the published abstract; every number is checked against it