Heart failure & cardiomyopathiesCohort study
Temporal Trends in Takotsubo Syndrome
- Registry-based cohort study
- international registry
- temporal trend analysis
Authors' conclusion
This study of temporal trends in TTS highlights a transition in patients demographic with a growing prevalence among men, increasing recognition of midventricular TTS type, and increased short-term mortality and rates of cardiogenic shock in recent years.
Study context
- Population
- Patients diagnosed with takotsubo syndrome (TTS) in the InterTAK registry, 2004–20216 groups of 3-year intervals
- Participants
- 3,957 patients
- Exposure
- Six 3-year intervals, 2004–2021
Main finding
As reported in the abstract
Proportion of male patients rose from 10% to 15%
P = 0.003
Midventricular TTS increased from 18% to 28%
P = 0.018
Physical triggers increased from 39% to 58%
P < 0.001
Significant increase in 60-day mortality over the years
P < 0.001
Observational data: associations, not effects.
Further findings
1-year mortality, landmark analysis excluding deaths within first 60 days
- No differences in 1-year mortality
- P = 0.150
Original publication
Summarised from the published abstract; every number is checked against it