Cohort study
Temporal trends in the incidence of malignancy in heart failure: a nationwide Danish study
- Retrospective cohort study
- nationwide registers
Authors' conclusion
Although cancer rates during 1997-2016 have remained stable within 1-6 years after the HF diagnosis, long-term survival following a HF diagnosis has increased significantly.
Study context
- Population
- Patients with heart failure (HF) alive, cancer-free and aged 30–80 years 1 year after HF diagnosis, Denmark, 1997–2016
- Participants
- 103,711 patients
- Exposure
- Index year 2016 vs 1997
- Outcome
- Incidence of new-onset cancer
- Follow-up
- 5 years
Main finding
Five-year incidence rate of cancer
Hazard ratio
1.09
CI 0.97–1.23
By group
2016 vs 1997
HR 1.09 (CI 0.97–1.23)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Five-year absolute risk of cancer | 1997-2001 9.0% · 2012-16 9.0% |
| Five-year cumulative incidence of survival | 1997-2001 55.9% · 2012-2016 74.3% |
| Age at index date | 1997-2001 median 70.3 (IQR 62.5–75.7) · Men 60.9% · 2012-16 median 67.6 (IQR 59.2–73.8) · Men 67.5% |
Five-year absolute risk of cancer
- Did not change with advancing calendar year
Original publication
Temporal trends in the incidence of malignancy in heart failure: a nationwide Danish study. Eur Heart J. Published 24 January 2023. doi:10.1093/eurheartj/ehac797
Summarised from the published abstract; every number is checked against it