Terminal renal failure as a contributor to high-sensitivity cardiac troponin T elevations: insights from patients undergoing renal transplantation
Authors' conclusion
Terminal renal failure is a non-cardiac cause of elevated circulating hs-cTnT concentrations, contributing more than one-third in this cohort, while the remaining two-thirds seem related to chronic cardiomyocyte injury.
Study context
- Population
- Patients with end-stage renal disease (ESRD) undergoing renal transplantation, excluding perioperative myocardial infarction or injurymedian age 67 years, 31% women
- Participants
- 45 patients
- Comparison
- High-sensitivity cTnT (hs-cTnT) and creatinine pretransplant vs post-transplant
Main finding
As reported in the abstract
Plasma creatinine concentration · pretransplant, day 1, days 2-5, days 14-180
Pretransplant median
608 μmol/L
IQR 482–830
Day 1 median
425 μmol/L
IQR 337–619
Days 2-5 median
289 μmol/L
IQR 201–492
Days 14-180 median
126 μmol/L
IQR 103–191
Further findings
hs-cTnT concentration · pretransplant, day 1, days 2-5, days 14-180
- Pretransplant median
- 48 ng/L (IQR 34-70)
- Day 1 median
- 26 ng/L (IQR 15-38)
- Day 1 geometric mean of relative change
- 36%
- Days 2-5 median
- 26 ng/L (IQR 18-35)
- Days 14-180 median
- 25 ng/L (IQR 20-30)
- Day 1 fall p<0.001
- Remained constant on days 2-5 and days 14-180, p=ns
Original publication
Terminal renal failure as a contributor to high-sensitivity cardiac troponin T elevations: insights from patients undergoing renal transplantation. Heart. Published 6 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it