Pulmonary vascular disease & thromboembolismCohort study
The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry
- multicentre European prospective cohort
- machine learning
Authors' conclusion
Incorporation of echocardiographic parameters improves risk scores in PAH.
Study context
- Population
- Patients with prevalent pulmonary arterial hypertension (PAH) enrolled in the ULTRA RIGHT VALUE study between January 2022 and December 2023patients with prevalent PAH
- Participants
- 401 patients
- Exposure
- European Society of Cardiology (ESC)/European Respiratory Society (ERS) and REVEAL 2.0 risk scores with vs without echocardiographic right ventricle (RV) variables
Main finding
As reported in the abstract
Odds of achieving/maintaining a low-risk status per one-unit decrease in any RV morphological parameter
ESC/ERS score: odds increased up to
69%
REVEAL score: odds increased up to
92%
Observational data: associations, not effects.
Further findings
| Outcome | c-index (95% CI) | P value |
|---|---|---|
| c-index for morbi-mortality prediction — ESC/ERS score with echocardiographic variables vs ESC/ERS score · improved from 0.73 (95% CI 0.69-0.76) | 0.78 (0.75–0.81) | P < 0.01 |
| c-index for morbi-mortality prediction — REVEAL 2.0 score with echocardiographic variables vs REVEAL 2.0 score · improved from 0.74 (95% CI 0.67-0.83) | 0.79 (0.76–0.82) | P < 0.01 |
Odds of achieving/maintaining a low-risk status per one-unit increase in any RV functional parameter
- ESC/ERS score: odds increased up to
- 1.28
- REVEAL score: odds increased up to
- 1.78
- Echocardiographic assessments of RV-PA coupling were the most performant
c-index for morbi-mortality prediction
- Machine learning: indexes of RV-PA coupling had the highest influence on the c-index
Original publication
The added value of echocardiography in pulmonary arterial hypertension risk assessment an artificial intelligence machine learning–derived analysis of the ULTRA RIGHT VALUE registry. Eur Heart J Cardiovasc Imaging. Published 17 September 2026. doi:10.1093/ehjci/jeag232
Summarised from the published abstract; every number is checked against it