HypertensionCross-sectional study
The association between fibrotic diseases and treatment-resistant hypertension in England
- Cross-sectional study
- primary care database (CPRD Aurum)
- multivariable logistic regression
Authors' conclusion
The proportion of people with fibrotic conditions was greater in those with treatment-resistant hypertension than managed hypertension.
Study context
- Population
- People with hypertension during 2015, England primary care (CPRD Aurum)
- Participants
- 1,340,495 people
- Exposure
- Treatment-resistant hypertension vs managed hypertension
- Treatment-resistant hypertensionn = 221,162
- Managed hypertensionn = 1,119,333reference
- Outcome
- Association between hypertension control and each fibrotic condition
Main finding
As reported in the abstract
Fibrotic conditions
Treatment-resistant hypertension vs Managed hypertensionAdjusted odds ratio (95% CI)
cardiomyopathy
1.85(1.81–1.90)
Type 1 diabetes
1.49(1.44–1.55)
Type 2 diabetes
1.61(1.60–1.63)
liver fibrosis
1.52(1.46–1.58)
valve fibrosis
1.41(1.37–1.44)
urinary fibrosis
1.41(1.36–1.47)
Observational data: associations, not effects.
Original publication
The association between fibrotic diseases and treatment-resistant hypertension in England. Eur J Prev Cardiol. Published 13 February 2025. doi:10.1093/eurjpc/zwaf068
Summarised from the published abstract; every number is checked against it