Heart failure & cardiomyopathiesSecondary analysis
The Association of Echocardiographically Measured Donor Left Ventricular Mass and 1-Year Outcomes After Heart Transplantation
- Secondary analysis of the Donor Heart Study prospective cohort
- multicentre
- observational
Authors' conclusion
Measuring donor LVM with the use of echocardiography may provide a more accurate method for donor-recipient heart size matching that could improve heart transplant outcomes, especially in obese recipients.
Study context
- Population
- Heart transplants from brain-dead donors with echocardiograms
- Participants
- 2,015 heart transplants
- Comparison
- Measured left ventricular mass (LVM) ratio vs ideally matched
- Primary endpoint
- Composite of:
- Death
- Retransplantation
- Follow-up
- 1 year
Primary result
As reported in the abstract
1-year death or retransplantation
Each group vs ideally matchedAdjusted hazard ratio (95% CI)
Undersized47% higher risk
1.47(1.01–2.15)
Oversized58% increased risk
1.58(1.05–2.37)
Further findings
Predicted heart mass (PHM) and predicted LVM ratios
- Not associated with the primary outcome
Prediction in obese recipients
- Measured LVM ratio had superior predictive power for poor post-transplant outcomes in obese recipients
Original publication
The Association of Echocardiographically Measured Donor Left Ventricular Mass and 1-Year Outcomes After Heart Transplantation. JACC Heart Fail. Published 20 November 2024. doi:10.1016/j.jchf.2024.10.001
Summarised from the published abstract; every number is checked against it