Congenital heart diseaseCross-sectional study
The association of single ventricle morphology with long term quality of life among survivors: A report from congenital heart disease project to understand lifelong survivor experience (congenital heart disease (CHD) PULSE)
- cross-sectional cohort study
- survey conducted from 2021 to 2023
- 11 US Pediatric Cardiac Care Consortium centers
Authors' conclusion
Ventricular morphology was not associated with differences in long-term outcomes. Adults with SV CHD have medical, neurocognitive, and socioeconomic differences compared to siblings, but similar PROMIS scores compared to the general population.
Study context
- Population
- Adults with single ventricle (SV) congenital heart disease (CHD) interventions and siblings226 SV patients and 40 siblings · SV patients 226 · siblings 40
- Participants
- 146 / 80 / 40
- Exposure
- left vs right ventricular morphology; SV CHD patients vs siblings
- left ventricularn = 146
- right ventricularn = 80
- siblingsn = 40
Main finding
As reported in the abstract
- No outcome differences were found between left and right ventricular groups
Observational data: associations, not effects.
Further findings
Medical comorbidities, future health concerns, disability benefits, work affected by health (SV patients vs siblings)
- SV patients reported more medical comorbidities
- P < 0.001
- SV patients reported more future health concerns
- 0.008
- SV patients reported more disability benefits
- P < 0.001
- SV patients reported more work affected by health
- P < 0.001
College/graduate degrees and employment (siblings vs SV patients)
- Siblings had higher rates of college/graduate degrees
- P = 0.002
- Siblings had higher rates of employment
- P = 0.044
Education and employment among SV patients
- SV patients completed high school
- 95.6%
- SV patients had college/graduate degrees
- 45.6%
- SV patients were employed
- 73.9%
Patient-Reported Outcomes Measurement Information System (PROMIS) scores (SV patients vs siblings)
- SV patients had lower PROMIS scores for global mental health and physical function
- Similar scores for global physical health, cognitive function, anxiety, depression, and ability to participate in social roles
Original publication
Summarised from the published abstract; every number is checked against it