Heart failure & cardiomyopathies
The Chronic Heart Failure Evolutions: Different Fates and Routes
Authors' conclusion
Each HF phenotype has a specific disease progression and prognosis.
Study context
- Population
- Chronic heart failure (HF) patients in the MECKI registry with a minimum 2-year follow-upfrom 7948 in registry
- Participants
- 4,876 patients
- Outcome
- Composite of:
- CV death
- Left ventricular assist device
- Urgent heart transplant
- Follow-up
- 5 years
Methodological detailsunsupervised learning: topological data analysis and trajectory analysis, internal and external validation
- Unsupervised learning: topological data analysis and trajectory analysis
- Internal and external validation
Main finding
As reported in the abstract
- Patient clusters identified by topological data analysis (TDA)
- 19
- Trajectory path: bifurcation points
- 3
- Trajectory path: end-stage points
- 4
- Cluster survival rate at 2 years
- 44% to 100%
- Cluster survival rate at 5 years
- 20% to 100%
- Composite event observed
- 22%
Observational data: associations, not effects.
Further findings
Validation of 5-year event frequency per cluster
- Internal validation cohort (n = 527)
- R = 0.94
- External validation cohort (n = 777)
- R = 0.84
- P < 0.001
Original publication
The Chronic Heart Failure Evolutions: Different Fates and Routes. ESC Heart Fail. Published 24 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →