Prevention & lipidsCohort study
The contribution of adolescent cardiovascular disease risk factors to vascular stiffness and cardiac remodelling in young adults
- Prospective cohort study
Authors' conclusion
An unhealthy CVD risk profile in adolescence leads to structural vascular and cardiac changes in young adults, predisposing them to future CVD.
Study context
- Population
- Raine Study participants classified at 17 years and re-studied at 27 years
- Participants
- 716 participants
- Exposure
- High vs low cardiovascular disease (CVD) risk at 17 years
- Outcome
- Vascular stiffness (PWV), LVMI, LV, right ventricular (RV) and left atrial (LA) myocardial strain and respective ejection fractions (EF) by CMR
- Follow-up
- 27 years
Main finding
As reported in the abstract
PWV and LVMI at 27 years
| Group | Pulse wave velocity (PWV), males | PWV, females | Left ventricular mass index (LVMI), males | LVMI, females |
|---|---|---|---|---|
| High-risk | 6.6 ± 0.12 m/sec | 6.2 ± 0.10 m/sec | 75.2 ± 2.1 g/m² | 55.4 ± 1.0 g/m² |
| Low-risk | 6.2 ± 0.04 m/sec | 5.6 ± 0.04 m/sec | 69.7 ± 0.5 g/m² | 52.1 ± 0.4 g/m² |
Observational data: associations, not effects.
Further findings
| Outcome | High-risk | Low-risk | P value |
|---|---|---|---|
| LV global longitudinal strain, females · 27 years · attenuated | −16.7 ± 0.4 % | −17.6 ± 0.17 % | P = 0.041 |
| LV global circumferential strain · 27 years | |||
| Males | −19.1 ± 0.5% | −20.5 ± 0.2% | P = 0.013 |
| Females | −21.3 ± 0.4% | −22.4 ± 0.2% | P = 0.022 |
- Left ventricular (LV) global circumferential strain: significant after adjusting for sex and contemporary risk factors
Original publication
The contribution of adolescent cardiovascular disease risk factors to vascular stiffness and cardiac remodelling in young adults. Eur J Prev Cardiol. Published 24 November 2025. doi:10.1093/eurjpc/zwaf739
Summarised from the published abstract; every number is checked against it