The COR Lipid Registry: the effectiveness of the strike early and strike strong strategy in patients with high cardiovascular risk
Authors' conclusion
An optimized LLT strategy for managing a very high CV risk patient cohort undergoing PCI, starting with a dual LLT strategy consisting of a high-dose, highly effective statin plus ezetimibe at the index event followed by addition of a third LL-agent (a PCSK9 inhibitor or bempedoic acid) at follow-up after 4-6 weeks if treatment goal was not reached, was highly effective in achieving LDL-C and non-HDL-C goals. Wider adoption of this strategy may help to significantly improve LDL-C target levels in real-world populations in very high-risk CAD patients presenting with ACS or CCS for coronary revascularization.
Study context
- Population
- Patients at very high cardiovascular (CV) risk presenting for percutaneous coronary intervention (PCI) with acute coronary syndrome (ACS) or chronic coronary syndrome (CCS), with LDL-C >130 mg/dL or non-HDL of 160 mg/dL, lipid-lowering therapy (LLT)-naïve or with suboptimal LLT at index hospitalizationvery high-risk patients included · CCS 79 · ACS 109
- Participants
- 165 patients
- Exposure
- ACS vs CCS vs LLT-naïve vs LLT-pre-treated
- ACSn = 109
- CCSn = 79
- LLT-naïven = 64
- Outcome
- Recommended lipid goal reached (LDL-C of < 55 mg/dL or non-HDL-C of 85 mg/dL)
- Follow-up
- Visit 1 and Visit 2
Main finding
As reported in the abstract
Visit 1
114
69.1%
Visit 2
160 patients
97%
Observational data: associations, not effects.
Further findings
| Outcome | ACS | CCS | LLT-naïve | LLT-pre-treated |
|---|---|---|---|---|
| Treatment goal reached, by admission type · Visit 1 and Visit 2 | ||||
| Visit 1 | 74.3% | 60.8% | — not stated in the abstract | — not stated in the abstract |
| Visit 2 | 97.3% | 100% | — not stated in the abstract | — not stated in the abstract |
| Treatment goal reached, by LLT status at admission · Visit 1 and Visit 2 | ||||
| Visit 1 | — not stated in the abstract | — not stated in the abstract | 61.5% | 76.3% |
| Visit 2 | — not stated in the abstract | — not stated in the abstract | 96.9% | 100% |
— not stated in the abstract
Original publication
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