The Correlation Between Albumin-Corrected Anion Gap and Prognosis in Patients with Acute Myocardial Infarction
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.423 95% CI 1.206–1.678Authors' conclusion
Elevated serum ACAG (≥20 mmol/L) is an independent risk factor for short-term and long-term mortality in critically ill patients with AMI, and it may assist clinicians and nurses identifying high-risk patients.
Study context
- Population
- Adult patients with acute myocardial infarction (AMI) in the MIMIC-IV (v2.0) database
- Participants
- 1,783 patients
- Exposure
- High vs normal albumin-corrected anion gap (ACAG)
- Outcome
- All-cause mortality
- Follow-up
- 30 and 360 days
Methodological detailsMIMIC-IV (v2.0) database
- MIMIC-IV (v2.0) database
Main finding
As reported in the abstract
Hazard ratio
1.423
95% CI 1.206–1.678
P < 0.001
High ACAGvs Normal ACAG
HR 1.423 (95% CI 1.206–1.678); P < 0.001
Observational data: associations, not effects.
Further findings
Non-linear relationship of ACAG with all-cause mortality (RCS) · 30 and 360 days
- 30 days χ2 = 10.750
- P = 0.013
- 360 days χ2 = 13.960
- P = 0.003
Cumulative survival (Kaplan-Meier) · 30 and 360 days
- Significantly lower with high ACAG at 30 days (log-rank χ2 = 98.880)
- P < 0.001
- Significantly lower with high ACAG at 360 days (log-rank χ2 = 105.440)
- P < 0.001
Prediction of 360 day mortality (ROC)
- AUC of ACAG
- 0.651
- AUC of AG
- 0.609
- AUC of ACAG combined with SOFA score
- 0.699
Original publication
The Correlation Between Albumin-Corrected Anion Gap and Prognosis in Patients with Acute Myocardial Infarction. ESC Heart Fail. Published 2 January 2024. doi:10.
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