The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis
Authors' conclusion
AP is cost-effective for preventing IE, particularly in those at high risk.
Study context
- Population
- Patients at risk of infective endocarditis undergoing dental procedures, England/UK
- Comparison
- Antibiotic prophylaxis vs no antibiotic prophylaxis
- Outcome
- Health service costs and benefits (QALYs); cost-effectiveness
Methodological detailsdecision analytic model
- Decision analytic model
Main finding
As reported in the abstract
Cost-effectiveness
Annual infective endocarditis (IE) reduction needed for antibiotic prophylaxis (AP) to be cost-effective at £20 000 ($26 600) per QALY, high-risk patients
1.44 cases
Annual IE reduction needed for AP to be cost-effective at £20 000 ($26 600) per QALY, all at-risk patients
33 cases
Annual cost savings from reinstating AP in England
£5.5 to £8.2 million
$7.3-$10.9 million
Health gains from reinstating AP in England
>2600 quality-adjusted life-years
Original publication
The Cost-Effectiveness of Antibiotic Prophylaxis for Patients at Risk of Infective Endocarditis. Circulation. Published 15 November 2016. doi:10.
Summarised from the published abstract; every number is checked against it