Heart failure & cardiomyopathiesCohort study
The diagnostic yield of an elaborate workup for comorbidities in a real-life heart failure with preserved ejection fraction outpatient population
- Prospective observational cohort study
- single-centre
Authors' conclusion
This study highlights the value of routine comorbidity screening in HFpEF, identifying one new comorbidity per patient on top of three pre-existing conditions, most commonly sleep apnoea or iron deficiency. Treatment of existing comorbidities was often suboptimal.
Study context
- Population
- HFpEF patients diagnosed via a specialized outpatient clinicage 75 ± 7 years, 67% female
- Participants
- 501 patients
- Outcome
- Diagnostic yield of standardized routine workup for comorbidities (laboratory testing, sleep apnoea screening, 24 h Holter, spirometry, exercise testing, 6 min walk test)
Main finding
As reported in the abstract
Known comorbidities before workup, median [IQR]
three [2-5]
Additional comorbidities diagnosed during workup
one
Newly diagnosed sleep apnoea
33%
Newly diagnosed iron deficiency
35%
Observational data: associations, not effects.
Further findings
Overall prevalence of comorbidities
- Hypertension
- 74%
- Sleep apnoea
- 52%
- AF
- 50%
- Iron deficiency
- 49%
- Obesity
- 45%
Pre-existing comorbidities without optimal guideline-directed therapy
- Diabetes
- 23%
- Hypercholesterolaemia
- 36%
- Obesity
- 45%
Original publication
Summarised from the published abstract; every number is checked against it