Heart failure & cardiomyopathiesMeta-analysis
The Different Risk of New-Onset, Chronic, Worsening, and Advanced Heart Failure: A Systematic Review and Meta-Regression Analysis
- Systematic review and meta-regression analysis of observational studies
- random effects meta-analysis
- mixed-effects meta-regression
Authors' conclusion
Our meta-analysis of observational studies confirms the different risk for adverse outcomes across the distinct HF stages.
Study context
- Population
- Heart failure (HF) patients in observational studies, 2012–2022
- Participants
- 862,046 patients · 66 studies
- Comparison
- New-onset HF vs chronic HF (CHF) vs worsening HF (WHF) vs advanced HF
- Outcome
- 30-day and 1-year all-cause mortality, and 1-year HF hospitalization
- Follow-up
- 30 days and 1 year
Pooled result
As reported in the abstract
1-year all-cause mortality · 1 year
Further pooled results
| Outcome | New-onset HF | CHF | WHF | Advanced HF | P value |
|---|---|---|---|---|---|
| 30-day all-cause mortality (hospital-admitted) · no significant distinction | 10.13% | Not reported in the abstract | 8.11% | Not reported in the abstract | P = 0.10 |
1-year HF readmission
- Followed a similar trend
Original publication
The Different Risk of New-Onset, Chronic, Worsening, and Advanced Heart Failure: A Systematic Review and Meta-Regression Analysis. Eur J Heart Fail. Published 24 November 2023. doi:10.1002/ejhf.3048
Summarised from the published abstract; every number is checked against it