Prevention & lipidsCohort study
The differential impact of abdominal obesity on fasting and non-fasting triglycerides and cardiovascular risk
- Cohort study
- UK Biobank
- polygenic score
Authors' conclusion
Polygenic score for abdominal obesity has a stronger effect on non-fasting than fasting TG levels, reflecting impaired postprandial lipid metabolism.
Study context
- Population
- UK Biobank participants with random TG levels and self-reported fasting duration
- Participants
- 352,782 participants
- Outcome
- Interaction of abdominal obesity (WHRadjBMI phenotype and polygenic score) with fasting duration on TG levels, and implications for CVD risk (MI and stroke incidence)
Main finding
As reported in the abstract
Interaction with fasting duration, waist-hip ratio adjusted for BMI (WHRadjBMI) phenotype
PInteraction= 6.5x10-32
Interaction with fasting duration, WHRadjBMI polygenic score
PInteraction=0.034
Polygenic score increased non-fasting TG more than fasting TG per SD increase in WHRadjBMI
0.1 mmol/L
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) risk by TG levels
- Higher TG levels, regardless of fasting status, associated with higher CVD risk
Association of WHRadjBMI polygenic score with CVD risk, adjusted for TG
- Attenuation after adjusting for non-fasting TG (HR=1.41 to HR=1.30)
- 27%
- Attenuation after adjusting for fasting TG (HR=1.38 to HR=1.34)
- 11%
Original publication
Summarised from the published abstract; every number is checked against it