Heart failure & cardiomyopathiesCohort study
The EAT-Lancet Diet Index, Plasma Proteins, and Risk of Heart Failure in a Population-Based Cohort
- Prospective cohort study
- population-based
- proteomic subcohort
Authors' conclusion
Higher adherence to the EAT-Lancet diet was associated with a lower risk of HF.
Study context
- Population
- Swedish population-based cohort; Heart failure (HF) cases identified through the Swedish national registerproteomic subcohort n = 4,742
- Participants
- 23,260 participants
- Exposure
- Higher vs lower adherence to the EAT-Lancet diet
- Outcome
- Incident HF
- Follow-up
- Median 25.0 years
Main finding
As reported in the abstract
Incident HF per 3-point increase of the EAT-Lancet diet index
Hazard ratio
0.93
95% CI 0.88–0.97
per 3-point increase of the EAT-Lancet diet index
HR 0.93 (95% CI 0.88–0.97)
Per 3-point increase of the EAT-Lancet diet, as printed
- Incident HF cases
- 1,768
Observational data: associations, not effects.
Further findings
Plasma proteins (136 included)
- Proteins inversely associated with the diet index and positively with HF risk (AM, GDF15, IL-6, TIM, CTSD, CCL20, FS, FUR)
- 8
- Proportion of the association mediated by the proteomic score
- 9.4% (95% CI: 2.2%-32.1%)
Original publication
The EAT-Lancet Diet Index, Plasma Proteins, and Risk of Heart Failure in a Population-Based Cohort. JACC Heart Fail. Published 3 April 2024. doi:10.1016/j.jchf.2024.02.017
Summarised from the published abstract; every number is checked against it