Arrhythmias & electrophysiologyMechanistic study
The effect of fixed and functional remodelling on conduction velocity, wavefront propagation, and rotational activity formation in atrial fibrillation
- Mechanistic study
- computational modelling
Authors' conclusion
Conduction velocity dynamics are impacted by the degree of scar. Conduction velocity heterogeneity and functional remodelling impacts wavefront propagation in SR and rotational activity burden in AF.
Study context
- Population
- Patients undergoing ablation for persistent atrial fibrillation (AF)2,768,400 LAT and voltage points
- Participants
- 60 patients
Main finding
As reported in the abstract
CV heterogeneity sites, pivot points and rotational activity burden by voltage and remodelling
Enhanced conduction velocity (CV) heterogeneity sites mapped to low-voltage zones (LVZs) (0.2-0.49 mV) rather than LVZs (<0.2 mV)
128/168, 76.2%
Enhanced CV heterogeneity sites co-located to pivot points
151/168, 89.9%
Original publication
The effect of fixed and functional remodelling on conduction velocity, wavefront propagation, and rotational activity formation in atrial fibrillation. Europace. Published 16 September 2024. doi:10.1093/europace/euae239
Summarised from the published abstract; every number is checked against it