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Heart failure & cardiomyopathiesMeta-analysis

The Effect of Sodium–Glucose Cotransporter 2 Inhibitors on Left Cardiac Remodelling in Heart Failure with Reduced Ejection Fraction: Systematic Review and Meta-Analysis

Eur J Heart FailPublished

  • Systematic review and meta-analysis of randomised trials
  • random-effects model
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Authors' conclusion

Sodium-glucose cotransporter 2 inhibitors improve cardiac structure and function in patients with HFrEF.

Study context

Population
Patients with heart failure with reduced ejection fraction (HFrEF)
Participants
555 patients · 6 trials
Comparison
SGLT2i vs control
Outcome
Left cardiac structure and function (remodelling indices)

Pooled result

As reported in the abstract

Left cardiac structure and function (pooled WMD, random-effects)
SGLT2i vs ControlWMD, ml (95% CI)P value
LVEDV
−17.07(−23.84 to −10.31)
P < 0.001
LVESV
−15.63(−26.15 to −5.12)
P = 0.004
SGLT2i vs ControlWMD, ml/m2 (95% CI)P value
LVEDV index
−5.62(−10.28 to −0.97)
P = 0.02
LVESV index
−6.90(−10.68 to −3.11)
P = 0.001
Left atrial volume index
−2.19(−4.26 to −0.11)
P = 0.04
SGLT2i vs ControlWMD, % (95% CI)P value
LVEF
2.71(0.70–4.72)
P = 0.008
SGLT2i vs ControlWMD, g/m2 (95% CI)P value
LV mass index; non-significant trend towards a reduction
−6.25(−12.79 to 0.28)
P = 0.06
No significant impact on LV global longitudinal strain
WMD: 0.21% [−0.25, 0.67]; p = 0.38

Original publication

The Effect of Sodium–Glucose Cotransporter 2 Inhibitors on Left Cardiac Remodelling in Heart Failure with Reduced Ejection Fraction: Systematic Review and Meta-Analysis. Eur J Heart Fail. Published 18 January 2024. doi:10.1002/ejhf.3129
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Summarised from the published abstract; every number is checked against it