Cohort study
The effect of statins on mortality and cardiovascular disease in primary care hypertensive patients without other cardiovascular disease or diabetes
- Retrospective cohort study
- propensity-score matched
- Swedish primary healthcare (PHC) quality assurance register QregPV
Authors' conclusion
Primary prevention with statins in PHC was associated with reduced risk of all-cause mortality, cardiovascular mortality, and in women, lower risk of MI.
Study context
- Population
- Primary healthcare individuals with hypertension without cardiovascular disease (CVD) or DMmatched on sex and propensity score
- Participants
- 13,193 vs 13,193
- Exposure
- Statins vs no statins for primary prevention
- Statinn = 13,193
- Controln = 13,193reference
- Outcome
- All-cause mortality, CV mortality, MI and stroke
- Follow-up
- Median 4.2 years
Main finding
As reported in the abstract
median 4.2 years
Statin
395
Deaths · CV deaths 197 · myocardial infarction (MI) 171 · Stroke 161
Control
475
Deaths · CV deaths 232 · MI 191 · Stroke 181
Statin vs ControlHazard ratio (95% CI)
all-cause mortality
0.83(0.74–0.93)
CV mortality
0.85(0.72–0.998)
MI
0.89(0.74–1.07)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MI, by sex (subgroup) — Statin vs Control · women | 0.66 (0.49–0.88) | |
| MI, by sex (subgroup) — Statin vs Control · men | 1.09 (0.86–1.38) | |
| 0.512Hazard ratio (log scale) |
- MI, by sex (subgroup): interaction P = 0.008
Original publication
The effect of statins on mortality and cardiovascular disease in primary care hypertensive patients without other cardiovascular disease or diabetes. Eur J Prev Cardiol. Published 27 June 2023. doi:10.1093/eurjpc/zwad212
Summarised from the published abstract; every number is checked against it