Heart failure & cardiomyopathies
The Effects of Early Exercise on Cardiovascular Biomarkers in Patients witH Congestive Heart Failure
Authors' conclusion
Early in-hospital exercise in AHF patients transiently elevates NT-proBNP and ET-1, indicative of acute haemodynamic stress, without altering myocardial injury or fibrosis markers (hs-TnT, sST2 and Gal-3). Elevated baseline hs-TnT and post-exercise NT-proBNP increases correlate with poorer survival, highlighting their prognostic value in risk assessment.
Study context
- Population
- Hospitalized acute congestive heart failure (AHF) patients undergoing early in-hospital supervised rehabilitation
- Participants
- 118 hospitalized AHF patients
- Comparison
- Biomarker measurement before and after supervised rehabilitation
- Exercise groupn = 83
- Controlsn = 35
- Outcome
- NT-proBNP
- Follow-up
- Post-intervention
Methodological details12-month follow-up
- 12-month follow-up
Main finding
As reported in the abstract
Exercise group
2900 ± 700 pg/mL to 3500 ± 760 pg/mL
- Increased significantly in the exercise group
- P = 0.012
Further findings
All-cause mortality · 12-month follow-up
| HR (95% CI) | ||
|---|---|---|
| Higher baseline hs-TnTIndependent predictor of mortality | 2.1 (1.3–3.4) | |
| Greater NT-proBNP elevation post-exercise (ΔNT-proBNP)Independent predictor of mortality | 1.8 (1.1–2.9) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Exercise group |
|---|---|
| ET-1 · Post-intervention | 1.9 ± 0.4 pg/mL to 2.4 ± 0.5 pg/mL |
- ET-1 — increased significantly
- P = 0.018
Hs-TnT, sST2 and Gal-3
- No significant changes
- all P > 0.05
Original publication
The Effects of Early Exercise on Cardiovascular Biomarkers in Patients witH Congestive Heart Failure. ESC Heart Fail. Published 19 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →