The effects of pregnancy in subjects with repaired tetralogy of Fallot
Authors' conclusion
Most ventricular remodeling parameters measured by CMR did not significantly change in subjects with rTOF who completed pregnancy or in nulliparous subjects with rTOF. In the pregnancy group, RVESVi is larger in those individuals who have undergone pregnancy without a significant change in ventricular function.
Study context
- Population
- Women with repaired tetralogy of Fallot (rTOF)matched cohort
- Participants
- 36 vs 72
- Exposure
- Pregnancy vs nulliparous women with repaired tetralogy of Fallot
- Pregnancyn = 36
- Comparisonn = 72reference
- Outcome
- Change in CMR ventricular remodeling parameters (RVEDVi, RVEF, right ventricular (RV) mass, pulmonary regurgitation, left ventricular (LV) volumes, LV ejection fraction (LVEF), LV mass) from baseline to follow-up CMR
- Follow-up
- Mean 3.1 years (pregnancy) and 2.7 years (comparison)
Methodological detailstwo-center, matched (age at baseline cardiac magnetic resonance (CMR), RV ejection fraction (RVEF), RVEDVi)
- Two-center
- Matched (age at baseline CMR, RVEF, RVEDVi)
Main finding
As reported in the abstract
RVEDVi, RVEF, RV mass, pulmonary regurgitation severity, LV volumes, LVEF, LV mass · baseline vs follow-up CMR
- No significant change from baseline to follow-up CMR in either group
- Mixed effects model adjusted for time between CMRs: no significant difference in rate of change between pregnancy and comparison groups
- Matched cohort
Observational data: associations, not effects.
Further findings
| Outcome | Pregnancy (baseline) | Pregnancy (follow-up) | P value |
|---|---|---|---|
| RVESVi, pregnancy group (baseline vs follow-up)Slight increase | 68.93 (SD 23.34) ml/m² | 72.97 (SD 25.24) mL/m² | P = 0.028 |
Original publication
The effects of pregnancy in subjects with repaired tetralogy of Fallot. Am Heart J. Published 26 April 2024. doi:10.
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