Valvular & structural heart diseaseResearch article

The Evolving Concept of Secondary Mitral Regurgitation Phenotypes

JACC Cardiovasc ImagingPublished

  • Narrative review

Study context

Population
Secondary mitral regurgitation (SMR): atrial (atrial secondary mitral regurgitation (aSMR)) and ventricular phenotypes

Main finding

As reported in the abstract

Phenotypic characteristics of atrial and ventricular SMR
  • aSMR: severe left atrial enlargement with preserved LV anatomy and function; different patterns of mitral annular distortion cause different aSMR phenotypes
  • Ventricular SMR: relation of SMR severity to LV dilation, degree of pulmonary hypertension and RV dysfunction are key phenotypic characteristics for prognosis and treatment response

Original publication

The Evolving Concept of Secondary Mitral Regurgitation Phenotypes. JACC Cardiovasc Imaging. Published 27 March 2024. doi:10.1016/j.jcmg.2024.01.012

Summarised from the published abstract; every number is checked against it