Arrhythmias & electrophysiology
The Heritability of Supraventricular Tachycardia
- classical biometrical twin study design
- nationwide
- Danish Twin Registry and the Danish National Patient Registry
+2 more
- nationwide
- Danish Twin Registry and the Danish National Patient Registry
Authors' conclusion
Based on a large nationwide population of monozygotic and same-sex dizygotic twins, this is the first study to quantify the genetic and environmental contributions to SVT.
Study context
- Population
- Monozygotic and same-sex dizygotic twin pairs born in Denmark, in which one or both members were diagnosed with supraventricular tachycardia (SVT) between 1977 and 2024twin pairs, at least one SVT diagnosis in 663 twin pairs · monozygotic pairs 12,006 · dizygotic pairs 20,318
- Participants
- 32,324 participants
- Exposure
- risk of SVT in monozygotic co-twins compared with dizygotic co-twins
- monozygotic co-twinsn = 12,006
- dizygotic co-twinsn = 20,318reference
Main finding
As reported in the abstract
Risk of SVT in the co-twin after an SVT diagnosis in the index-twin
monozygotic co-twins vs dizygotic co-twinsHazard ratio (95% CI)P value
Risk of SVT in the co-twin after an SVT diagnosis in the index-twin
3.61(1.35–9.63)
P = 0.01adjusting for age and sex
3.3(1.24–8.89)
P = 0.01Observational data: associations, not effects.
Further findings
Probandwise concordance rate
- Probandwise concordance rate: P < 0.001
Biometrical models: attribution of SVT risk
- genetics
- 35%
- unique environmental components
- 65%
Original publication
The Heritability of Supraventricular Tachycardia. JACC Clin Electrophysiol. Published 22 January 2026. doi:10.1016/j.jacep.2025.12.021
Summarised from the published abstract; every number is checked against it