Heart failure & cardiomyopathies
The ICAM1 p.K56M variant and risk of heart failure in chronic kidney disease: the Chronic Renal Insufficiency Cohort study
Main finding · Incident HFpEFResult — go to the resultHazard ratio 1.35 95% CI 1.03–1.76Authors' conclusion
The ICAM1 p.K56M variant is specifically associated with increased risk of incident HFpEF among individuals with CKD.
Study context
- Population
- Black individuals with chronic kidney disease (CKD), aged 21–74 years with estimated glomerular filtration rate (eGFR) of 20–70 mL/min/1.73 m 2 at baseline, free from heart failure (HF) at baselineBlack participants (mean age 57±11 years, 51% female, mean eGFR 45±15 mL/min/1.73 m 2 )
- Participants
- 1,267 individuals
- Exposure
- associations of rs5491 with incident HF and HF subtypes
- rs5491n = 464
Main finding
Incident HFpEF · median follow-up of 10.3 years
Hazard ratio
1.35
95% CI 1.03–1.76
P = 0.029
Each additional rs5491 allele
HR 1.35 (95% CI 1.03–1.76); P = 0.029
Each additional rs5491 allele, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incident overall HF · median follow-up of 10.3 years
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| rs5491 · not associated | 1.14 (0.93–1.39) | P = 0.20 | |
| 0.512Hazard ratio (log scale) |
Incident HF with reduced ejection fraction (HFrEF) · median follow-up of 10.3 years
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| rs5491 · not associated | 0.76 (0.53–1.10) | P = 0.15 | |
| 0.512Hazard ratio (log scale) |
Incident HF hospitalisations · median follow-up of 10.3 years (IQR: 4.7-15.0 years)
- Overall HF hospitalisations
- 309
- HFpEF
- 160
- HFrEF
- 111
- HF with unknown ejection fraction
- 38
Original publication
The ICAM1 p.K56M variant and risk of heart failure in chronic kidney disease: the Chronic Renal Insufficiency Cohort study. Heart. Published 6 February 2025. doi:10.
Summarised from the published abstract; every number is checked against it