Valvular & structural heart diseaseCohort study
The Impact of Cerebral Embolic Protection Devices on Characteristics and Outcomes of Stroke Complicating Transcatheter Aortic Valve Replacement (TAVR)
- Registry-based cohort study
- international multicentre registry
- propensity-score matched analysis
Authors' conclusion
In a large cohort of patients with AISCT, the use of CEPD had little effect on stroke distribution, severity, and outcomes.
Study context
- Population
- Patients with acute ischemic stroke within 72 hours of TAVR (acute ischemic stroke complicating TAVR (AISCT))AISCT in 18,725 TAVR
- Participants
- 416 patients
- Exposure
- Cerebral embolic protection devices (CEPD)-protected TAVR vs unprotected TAVR
- CEPD-n = 376reference
- CEPD+n = 40
- Outcome
- Disabling stroke (modified Rankin Score >1) at 30 days and 6-month all-cause death
- Follow-up
- 30 days; 6 months
Main finding
As reported in the abstract
Disabling stroke at 30 days
P = 0.62
6-month mortality
P = 0.61
Observational data: associations, not effects.
Further findings
Disabling stroke and 6-month mortality, propensity-score matched cohort · matched cohort
Disabling stroke
P = 0.16
6-month mortality
P = 0.35
Middle cerebral artery stroke
P = 0.71
Internal carotid artery occlusion
Vertebrobasilar system strokes
P = 0.04
Severe stroke (NIHSS ≥15)
P = 0.20
Original publication
The Impact of Cerebral Embolic Protection Devices on Characteristics and Outcomes of Stroke Complicating TAVR. JACC Cardiovasc Interv. Published 11 March 2024. doi:10.1016/j.jcin.2023.12.033
Summarised from the published abstract; every number is checked against it