Prevention & lipidsMeta-analysis
The impact of lipid apheresis on changes of lipoprotein(a): a systematic review and meta-analysis
- Systematic review and meta-analysis
- random-effects model
- subgroup and meta-regression analyses
Authors' conclusion
Lipid apheresis is effective in significantly lowering serum Lp(a) concentrations across a range of patient groups and treatment modalities.
Study context
- Population
- Participants undergoing lipid apheresis in a wide array of disorders, particularly CVD43 publications
- Participants
- 2,466 participants · 67 studies
- Comparison
- Post- vs pre-lipid apheresis Lp levels
- Outcome
- Change in serum Lp(a) levels
Pooled result
Serum Lp(a)
SMD
−1.52
95% CI −1.76 to −1.29
P < 0.001
Post-apheresis vs Pre-apheresis
SMD −1.52 (95% CI −1.76 to −1.29); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Serum Lp(a), one-session lipid apheresis studies (n = 6) | −1.51 (−1.72 to −1.29) | P < 0.001 | |
| −2−101Difference (linear scale) |
Subgroups by Lp(a) detection method, disease background and initial Lp(a)
- Significant reductions across subgroups
Sources of heterogeneity (meta-regression)
- Publication year and disease background contributed to heterogeneity
Original publication
The impact of lipid apheresis on changes of lipoprotein(a): a systematic review and meta-analysis. Eur J Prev Cardiol. Published 24 February 2026. doi:10.1093/eurjpc/zwag089
Summarised from the published abstract; every number is checked against it