Heart failure & cardiomyopathiesDiagnostic or prognostic study
The MagMa Study
- Prospective diagnostic accuracy study
- 1:2 matched controls (age decade and sex)
Authors' conclusion
MCG offers a noninvasive, reproducible methodology for rapid and accurate detection of CM after exclusion of ischemic heart disease.
Study context
- Population
- Adults with angina-like symptoms and suspected cardiomyopathy after exclusion of CAD, from ED, inpatient wards and outpatient clinics; healthy matched controls110 patients · 220 controls
- Participants
- 330 adults
- Comparison
- Magnetocardiography (MCG) vs advanced imaging and/or endomyocardial biopsy
- Outcome
- Diagnostic accuracy of MCG for CM
Performance
As reported in the abstract
Detection of CM
| Test or model | Sensitivity | Specificity | NPV | PPV |
|---|---|---|---|---|
| MCG | 94.74% (95% CI: 85%-99%) | 98.54% (95% CI: 96%-100%) | 93.1% (95% CI: 84%-98%) | 94.34% (95% CI: 84%-98%) |
Further findings
Cardiomyopathy (CM) missed by CMR
- Patients in whom CMR failed to detect CM while MCG was pathologic, consistent with endomyocardial biopsy
- 3
Reproducibility
- Statistical uncertainty
- 2.5%
- MCG score (T-beg-Tmax) uncertainty
- ±0.004
Original publication
The MagMa Study. JACC Heart Fail. doi:10.1016/j.jchf.2026.103182
Summarised from the published abstract; every number is checked against it