Heart failure & cardiomyopathies
The Metabolic Vulnerability Index: A Novel Marker for Mortality Prediction in Heart Failure
An erratum to this article was published (JACC Heart Fail, Jun 2024 ↗)
Authors' conclusion
In this HF community cohort, MVX was strongly associated with mortality independently of established clinical factors and improved mortality risk classification beyond clinically validated markers.
Study context
- Population
- Patients with heart failure (HF), population-based cohort, 2003–2012, followed until March 31, 2021
- Participants
- 1,382 patients
- Exposure
- MVX score groups 2, 3 and 4 vs lowest MVX group
- Outcome
- Mortality
Methodological detailspopulation-based, community cohort
- Population-based
- Community cohort
Main finding
As reported in the abstract
Hazard ratio (95% CI)
MVX group 2vs Lowest MVX
1.2(0.9–1.4)
MVX group 3vs Lowest MVX
1.6(1.3–2.0)
MVX group 4vs Lowest MVX
1.8(1.4–2.2)
Observational data: associations, not effects.
Further findings
Risk classification of death
- MVX added value for classifying risk of death beyond MAGGIC score and other biomarkers
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Metabolic Vulnerability Index: A Novel Marker for Mortality Prediction in Heart Failure. JACC Heart Fail. Published 19 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →