The Ongoing Relationship Between Offspring Congenital Heart Disease and Preeclampsia Across Pregnancies
Main finding · Offspring CHD with preeclampsia in the same pregnancyResult — go to the resultAdjusted odds ratio 1.38 99% CI 1.29–1.49Study context
- Population
- Singleton pregnancies (23–42 weeks) delivered in California 2000–2012, excluding pre-existing diabetes and identified fetal chromosomal anomalies
- Exposure
- Association between preeclampsia and offspring congenital heart disease (CHD), within and across pregnancies
- Outcome
- Association between offspring CHD and preeclampsia (adjusted OR)
Methodological detailspopulation-based, multivariable logistic regression
- Population-based
- Multivariable logistic regression
Main finding
As reported in the abstract
Offspring CHD with preeclampsia in the same pregnancy
Adjusted odds ratio
1.38
99% CI 1.29–1.49
Preeclampsia
aOR 1.38 (99% CI 1.29–1.49)
Observational data: associations, not effects.
Further findings
Fetal CHD in subsequent pregnancy after preeclampsia in index pregnancy
| aOR (99% CI) | ||
|---|---|---|
| Preeclampsia in index pregnancy | 1.39 (1.20–1.61) | |
| 0.512Adjusted odds ratio (log scale) |
Preeclampsia in subsequent pregnancy after offspring CHD in index pregnancy
| aOR (99% CI) | ||
|---|---|---|
| Offspring CHD in index pregnancy | 1.39 (1.15–1.68) | |
| 0.512Adjusted odds ratio (log scale) |
All 3 analyses stratified by delivery <34 and ≥34 weeks (subgroup)
- Results remained significant in both strata
Original publication
The Ongoing Relationship Between Offspring Congenital Heart Disease and Preeclampsia Across Pregnancies. JACC Adv. Published 1 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →