Valvular & structural heart diseaseCohort study
The Prognostic Value of the Dandel's Index in Patients Undergoing Tricuspid Transcatheter Edge-to-Edge Repair
- Retrospective registry study
- EuroTR registry
Authors' conclusion
Assessment of the RV capacity to adjust for changes in loading conditions predicted mortality in patients with severe symptomatic TR undergoing T-TEER.
Study context
- Population
- Patients with relevant tricuspid regurgitation (TR) undergoing tricuspid transcatheter edge-to-edge repair (T-TEER), EuroTR registry 2019–2022, ≥2 years follow-up
- Participants
- 364 patients
- Exposure
- Right ventricular (RV) function parameters and Dandel's index as predictors of mortality
- Outcome
- All-cause mortality
- Follow-up
- 2 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Dandel's index
0.67(0.53–0.85)
TAPSE
0.72(0.62–0.84)
FAC
0.73(0.59–0.91)
TAPSE/sPAP
0.8(0.65–0.99)
- Died at 2-year follow-up
- 36%
- Dandel's index maintained predictive value in multivariate model, with TAPSE and absence of signs of right HF
- P < 0.001
- Optimal Dandel's index threshold (ROC)
- 20.5
Observational data: associations, not effects.
Further findings
Cardiac hospital readmission
- Dandel's index threshold of 20.5 also predicted cardiac hospital readmission
Original publication
The Prognostic Value of the Dandel's Index in Patients Undergoing Tricuspid Transcatheter Edge-to-Edge Repair. Eur J Heart Fail. Published 2 December 2024. doi:10.1002/ejhf.3532
Summarised from the published abstract; every number is checked against it