Prevention & lipidsCohort study
The relationship between low levels of albuminuria and mortality among adults without major cardiovascular risk factors
- Prospective cohort study
Authors' conclusion
Adults with elevated levels of albuminuria within the low range (UACR <30 mg/g) and no major cardiovascular risk factors had elevated risks of cardiovascular and all-cause mortality. The risk increased linearly with higher albuminuria levels.
Study context
- Population
- Adults without major CV risk factors (no CVD, hypertension, DM, pre-diabetes, eGFR <60, pregnancy or dialysis), NHANES 1999–2014NHANES 1999–2014
- Participants
- 12,835 adults
- Exposure
- Higher vs lower urinary albumin-to-creatinine ratio (UACR) within the low range
- Outcome
- CV mortality
- Follow-up
- Median 12.3 years
Main finding
CV death
Hazard ratio
1.36
95% CI 1.02–1.82
By group
UACR <4.18 mg/g
0.91
15-year adjusted cumulative incidence · %
UACR 4.18 to <6.91 mg/g
0.99
15-year adjusted cumulative incidence · %
UACR ≥6.91 mg/g
2.1%
15-year adjusted cumulative incidence
Each doubling of UACR
HR 1.36 (95% CI 1.02–1.82)
Each doubling of UACR, as printed
As reported in the abstract
- Participants with CV mortality
- 110
Observational data: associations, not effects.
Further findings
| Outcome | UACR <4.18 mg/g | UACR 4.18 to <6.91 mg/g | UACR ≥6.91 mg/g | HR (95% CI) | |
|---|---|---|---|---|---|
| All-cause mortality · multivariable-adjusted | 15-year adjusted cumulative incidence 5.1 % | 15-year adjusted cumulative incidence 6.1 % | 15-year adjusted cumulative incidence 7.4% | 1.24 (1.10–1.39) | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality — Participants with all-cause mortality
- 621
Original publication
The relationship between low levels of albuminuria and mortality among adults without major cardiovascular risk factors. Eur J Prev Cardiol. Published 3 June 2024. doi:10.1093/eurjpc/zwae189
Summarised from the published abstract; every number is checked against it