The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events: A Multicenter Study
Authors' conclusion
Early revascularization was associated with reduced risk in patients with a higher burden of quantitative ischemia in more recent populations.
Study context
- Population
- Patients undergoing myocardial perfusion imaging at 12 centres (original 2009–2014 and recent 2014–2021 registry sites)
- Participants
- 40,449 patients
- Exposure
- Early revascularization vs no early revascularization, by quantitative ischemia
- Outcome
- Death or MI; ischemia threshold at which HR for early revascularization crosses 1
Methodological detailsmulticentre, propensity-score adjusted, registry, Median follow-up 3.5 (IQR: 2.4-4.6) years
- Multicentre
- Propensity-score adjusted
- Registry
- Median follow-up 3.5 (IQR: 2.4-4.6) years
Main finding
As reported in the abstract
Death or MI · median follow-up 3.5 years
Death or myocardial infarction (MI) events (overall)
2,797
6.9%
Early revascularization associated with reduced death or MI with myocardial ischemia above
>9.0%
95% upper CI of ischemia threshold
11.2%
Observational data: associations, not effects.
Further findings
Ischemia threshold for potential benefit, recent vs original registry sites (subgroup)
- Recent
- 14.0%
- Original
- 6.5%
Ischemia threshold for potential benefit, by sex (subgroup)
- Female
- >10.0%
- Male
- >8.6%
- Similar in female and male patients
Original publication
The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events: A Multicenter Study. JACC Adv. Published 12 December 2024. doi:10.
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