Arrhythmias & electrophysiology
The Risk of Breakthrough Cardiac Events Associated With Psychiatric Medications in Patients With Diagnosed and Clinically Treated Long QT Syndrome
Authors' conclusion
After correct diagnosis and treatment, LQTS patients with concomitant mental health issues may be safely and effectively treated with QT-prolonging psychiatric medications.
Study context
- Population
- Patients with diagnosed and clinically treated Long QT syndrome (LQTS) and a concomitant psychiatric diagnosis requiring QT-prolonging medications, Mayo Clinic, 2000–2023of 1,787 LQTS patients
- Participants
- 195 patients
- Outcome
- Incidence of breakthrough cardiac events (BCEs) on QT-prolonging psychiatric medications
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
≥1 BCE after first Mayo Clinic evaluation
Patients with ≥1 BCE after first Mayo Clinic evaluation
14 of 195
7%
Of these, on psychiatric medications
3
21%
Observational data: associations, not effects.
Further findings
- Patients with ≥1 BCE before first Mayo Clinic evaluation
- 61 of 195 (31%)
- Of these, on psychiatric medications
- 7 (11%)
Original publication
The Risk of Breakthrough Cardiac Events Associated With Psychiatric Medications in Patients With Diagnosed and Clinically Treated Long QT Syndrome. JACC Clin Electrophysiol. Published 4 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →