Arrhythmias & electrophysiologyCohort study
The role for ambulatory electrocardiogram monitoring in the diagnosis and prognostication of Brugada syndrome: a sub-study of the Rare Arrhythmia Syndrome Evaluation (RASE) Brugada study
- Retrospective cohort study
- sub-study of the RASE Brugada study
- 1651 resting high precordial lead (HPL) and 621 ambulatory monitoring electrocardiogram (ECGs) reviewed
Authors' conclusion
Repeated ECG evaluation and HPL ambulatory monitoring are vital in identifying transient spT1 Brugada pattern and its associated risk.
Study context
- Population
- Brugada syndrome subjects with HPL resting and ambulatory monitoring ECGs
- Participants
- 358 subjects
- Exposure
- spT1 pattern at presentation vs none
- Group 1n = 77
- Group 2n = 281reference
- Outcome
- Identification of spT1 on repeat HPL resting and ambulatory ECG, and its association with ventricular dysrhythmias and sudden cardiac death (SCD)
- Follow-up
- Median 72 months
Main finding
As reported in the abstract
spT1 detection during follow-up · median 72 months (IQR 75)
| Group | Value | Newly detected spT1 rate | spT1 on HPL ambulatory recording |
|---|---|---|---|
| Group 1 | 55% | ||
| Group 2 | 13% | 1.9 per 100 person-year | 23 (8%) |
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Arrhythmic events by spT1 — spT1 at presentation vs Group 2 · univariate | 6.3 (1.4–28) | P = 0.016 | |
| Arrhythmic events by spT1 — spT1 at follow-up vs Group 2 · univariate | 3.1 (1.3–7.2) | P = 0.008 | |
| 0.050.21520Hazard ratio (log scale) |
- Arrhythmic events by spT1 — Previously asymptomatic subjects with arrhythmic events (5 with spT1)
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Original publication
The role for ambulatory electrocardiogram monitoring in the diagnosis and prognostication of Brugada syndrome: a sub-study of the Rare Arrhythmia Syndrome Evaluation (RASE) Brugada study. Europace. Published 8 April 2024. doi:10.1093/europace/euae091
Summarised from the published abstract; every number is checked against it