Valvular & structural heart disease
The Ross Renaissance: Trends and Short-Term Outcomes of the Ross Procedure in the United States
Main finding · Composite of in-hospital mortality, stroke, prolonged mechanical ventilation, reoperation, acute kidney injury, sepsis, cardiac arrest, and venous thromboembolismResult — go to the resultAdjusted odds ratio 0.65 95% CI 0.46–0.91Authors' conclusion
The Ross procedure is undergoing a resurgence in pediatric and adult populations, with favorable short-term outcomes and comparable costs to SAVR. These findings support broader adoption of the Ross operation at experienced centers for appropriately selected patients.
Study context
- Population
- Adult and pediatric patients undergoing elective aortic valve replacement
- Participants
- 109,235 valve replacements
- Exposure
- Ross procedure vs surgical aortic valve replacement (SAVR)
- Outcome
- Composite of:
- In-hospital mortality
- Stroke
- Prolonged mechanical ventilation
- Reoperation
- Acute kidney injury
- Sepsis
- Cardiac arrest
- Venous thromboembolism
Methodological detailsage-matched using coarsened exact matching, multivariable regression
- Age-matched using coarsened exact matching
- Multivariable regression
Main finding
As reported in the abstract
Adjusted odds ratio
0.65
95% CI 0.46–0.91
Rossvs SAVR
adjusted OR 0.65 (95% CI 0.46–0.91)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted OR (95% CI) | |
|---|---|---|
| StrokeLower odds with Ross · after age-matching and risk adjustment | 0.38 (0.18–0.80) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Nonhome discharge and 30-day readmissions
- Lower nonhome discharge and lower 30-day readmissions with Ross
Hospitalization costs
- Not significantly different between groups
Share of Ross procedures among valve replacements
- Adult cases
- 1.5%
- Pediatric cases
- 37.2%
Ross utilization over time
- Increased significantly over time across age groups
- P < 0.001
Baseline characteristics
- Ross recipients younger, with fewer comorbidities, often treated at high-volume teaching hospitals
Original publication
The Ross Renaissance: Trends and Short-Term Outcomes of the Ross Procedure in the United States. JACC Adv. Published January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →