Heart failure & cardiomyopathies
The Short and Long-Term Characteristics and Outcomes of Patients with Grade 1 Myocardial Uptake on Cardiac Scintigraphy
Main finding · SurvivalResult — go to the resultHazard ratio 0.271 95% CI 0.130–0.563Authors' conclusion
Patients with suspected ATTR-CA and a grade 1 scintigraphy uptake demonstrate a stable clinical, laboratory, imaging, and scintigraphy phenotype along with a benign survival profile at long-term follow-up.
Study context
- Population
- Patients suspected for ATTR-CA (clinical and echocardiographic parameters)
- Participants
- 132 patients
- Exposure
- Grade 1 vs grades 2/3 technetium pyrophosphate uptake on cardiac scintigraphy
- Grade 1n = 89
- Grades 2/3n = 43reference
- Outcome
- Final diagnosis and prognosis of patients with grade 1 uptake
Methodological detailsprospective long-term re-evaluation of grade 1 patients
- Prospective long-term re-evaluation of grade 1 patients
Main finding
Survival · 2 [IQR 0.75, 3.25] years follow-up
Hazard ratio
0.271
95% CI 0.130–0.563
P = 0.0005
Events by group
Grade 1
7%
6 of 89
Grade 1vs Grades 2/3
HR 0.271 (95% CI 0.130–0.563); P = 0.0005
As reported in the abstract
Observational data: associations, not effects.
Further findings
Long-term re-evaluation of grade 1 patients · median 3.2 (IQR 2.2, 3.9) years
- Grades 2/3 uptake at repeated scintigraphy
- 0/25
- NYHA class, biomarker levels and echocardiography findings remained stable
- 30 grade 1 patients re-evaluated
Baseline characteristics, grade 1 vs grades 2/3
- Grade 1 younger, female predominant, lower biomarker levels and LV mass
Original publication
The Short and Long-Term Characteristics and Outcomes of Patients with Grade 1 Myocardial Uptake on Cardiac Scintigraphy. ESC Heart Fail. Published 17 February 2023. doi:10.
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