Heart failure & cardiomyopathiesMechanistic study
The Transcriptional Profile of Iron Deficiency in Patients with Heart Failure: Heme-Sparing and Reduced Immune Processes
- Mechanistic study
- transcriptome profiling in whole blood
- in vitro stem cell-derived cardiomyocyte iron deficiency (ID) model
Authors' conclusion
Iron deficiency is associated with the preservation of heme-related processes at the cost of iron-sulfur clusters. Immune processes are downregulated, uncovering another high energy demand system affected.
Study context
- Population
- Patients with heart failure (HF) from the BIOSTAT-CHF cohort
- Participants
- 881 patients
- Comparison
- ID vs non-ID
- IDn = 554
Main finding
As reported in the abstract
Differentially expressed genes, ID vs non-ID
ID
62.9%
554 of 554
- Differentially expressed genes between ID and non-ID
- 89
- Upregulated genes
- 60
- Downregulated genes
- 29
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality in HF by SIAH2 and CLIC4 expression — SIAH2 vs non-ID | 2.40 (1.86–3.11) | P < 0.001 | |
| Mortality in HF by SIAH2 and CLIC4 expression — CLIC4 vs non-ID | 1.78 (1.53–2.07) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
The Transcriptional Profile of Iron Deficiency in Patients with Heart Failure: Heme-Sparing and Reduced Immune Processes. Eur J Heart Fail. Published 26 December 2024. doi:10.1002/ejhf.3562
Summarised from the published abstract; every number is checked against it