Prevention & lipidsCohort study
Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a)
- Prospective cohort study
- Women's Health Study
- hypothesis formulated after data collection
Authors' conclusion
Per the results of this cohort study, very high lipoprotein(a) levels correlated with increased 30-year risk of cardiovascular disease among healthy women.
Study context
- Population
- Healthy female health professionals without CVD, cancer or other major chronic illness at baseline, Women's Health Study, 1993–202323,279 with rs3,798,220 genotype
- Participants
- 27,748 professionals
- Exposure
- Lipoprotein(a) clinical thresholds and percentiles; LPA rs3798220 minor allele carriers vs non-carriers
- Outcome
- Incident major CV events, CHD, ischemic stroke and CV death
- Follow-up
- 30 years
Main finding
As reported in the abstract
Multivariable-adjusted HRs by lipoprotein(a) threshold · median follow-up 27.8 years
Hazard ratio (95% CI)
>120 mg/dL vs <10 mg/dLmajor CV events
1.54(1.24–1.92)
>99th percentile vs <50th percentilemajor CV events
1.74(1.35–2.25)
>120 mg/dL vs <10 mg/dLCHD
1.80(1.36–2.37)
>99th percentile vs <50th percentileCHD
2.06(1.49–2.84)
>120 mg/dL vs <10 mg/dLischemic stroke
1.41(0.93–2.15)
>99th percentile vs <50th percentileischemic stroke
1.85(1.17–2.93)
>120 mg/dL vs <10 mg/dLCV death
1.63(1.16–2.28)
>99th percentile vs <50th percentileCV death
1.86(1.26–2.72)
Observational data: associations, not effects.
Further findings
Major CV events by LPA rs3798220 genotype (European ancestry)
- rs3798220 minor allele carriers had a higher risk of major CV events
- 3165 major CV events among 23 279 women with genotype information
Original publication
Thirty-Year Risk of Cardiovascular Disease Among Healthy Women According to Clinical Thresholds of Lipoprotein(a). JAMA Cardiol. Published 1 February 2026. doi:10.1001/jamacardio.2025.5043
Summarised from the published abstract; every number is checked against it