Arrhythmias & electrophysiologyCohort study
Three-year clinical outcomes of left atrial appendage occlusion with or without ablation: insight from the RECORD study
- Prospective registry study
- propensity-score matched
- multicentre
Authors' conclusion
LAAO plus ablation was associated with a lower risk of a composite of cardiovascular death, stroke, and systemic embolism than LAAO only at 3-year.
Study context
- Population
- Patients who successfully received the WATCHMAN left atrial appendage occlusion (LAAO) device, 39 sites in China, 2019–2020matched cohort n = 2032
- Participants
- 2,928 patients
- Exposure
- LAAO plus ablation vs LAAO only
- LAAO plus ablationn = 1,016
- LAAOn = 1,016reference
- Outcome
- Composite of:
- CV death
- Stroke
- Systemic embolism
- Follow-up
- 3-year
Main finding
As reported in the abstract
Hazard ratio
0.66
95% CI 0.49–0.89
P = 0.007
By group
LAAO plus ablation vs LAAO
HR 0.66 (95% CI 0.49–0.89); P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | LAAO plus ablation | LAAO | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| CV death · 3-year · propensity-score matched | 3.7% | 7.3% | 0.50 (0.34–0.74) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Safety
BARC-defined bleeding
- No significant between-group differences
Original publication
Three-year clinical outcomes of left atrial appendage occlusion with or without ablation: insight from the RECORD study. Europace. Published 5 February 2026. doi:10.1093/europace/euag022
Summarised from the published abstract; every number is checked against it