Cardio-oncology & otherRandomised controlled trial
Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial
- Randomised controlled trial
- parallel-group
Authors' conclusion
There was no statistical difference in CRF improvement between concurrent vs. sequential exercise therapy relative to usual care in women with primary breast cancer.
Study context
- Population
- Inactive women with breast cancer initiating (neo)adjuvant chemotherapyn = 39/40 per group
- Participants
- 158 women
- Comparison
- Timing of exercise therapy vs usual care during and after chemotherapy
- Primary endpoint
- VO2peak change: concurrent exercise vs usual care during chemotherapy compared with sequential exercise vs usual care after chemotherapy
Primary result
As reported in the abstract
VO2peak change (concurrent vs usual care during chemotherapy vs sequential vs usual care after chemotherapy)
Overall difference
−0.88 mL O2·kg-1·min-1
95% CI −3.36 to 1.59
P = 0.48
Concurrent vs Sequential
overall difference −0.88 mL O2·kg-1·min-1 (95% CI −3.36 to 1.59); P = 0.48
Further findings
- VO2peak change from baseline to post-intervention, continuous exercise
- 1.74 · mL O2·kg-1·min-1
- VO2peak change from baseline to post-intervention, continuous exercise — Continuous exercise the only strategy with significant VO2peak improvement
- P < 0.001
Original publication
Timing of exercise therapy when initiating adjuvant chemotherapy for breast cancer: a randomized trial. Eur Heart J. Published 21 February 2023. doi:10.1093/eurheartj/ehad085
Summarised from the published abstract; every number is checked against it